Log in
RegisterNot blinding sampling times [Bioanalytics]
Hi Helmut,
» Even if substantial carry-over is not apparent in method validation (which would call for injecting mobile phase between samples), it exists. The EMA’s GL tells us [...]
Going by that guideline, will it be safe to say that the converse it also true. That is:
Well, just as you said, carryover is always very likely. Thus complete randomisation will not be the reasonable path to follow.
Thanks guys, at least I am glad I let my thoughts out and not get drowned in them.
» Even if substantial carry-over is not apparent in method validation (which would call for injecting mobile phase between samples), it exists. The EMA’s GL tells us [...]
Going by that guideline, will it be safe to say that the converse it also true. That is:
If it appears there is no carry-over, study samples should be randomised
Well, just as you said, carryover is always very likely. Thus complete randomisation will not be the reasonable path to follow.
Thanks guys, at least I am glad I let my thoughts out and not get drowned in them.
—
Scopy
Scopy
Complete thread:
- Blinding in Bioanalysis Obinoscopy 2018-08-19 16:22 [Bioanalytics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Blinding in Bioanalysis ElMaestro 2018-08-19 18:46
- Not blinding sampling times Helmut 2018-08-19 19:06
- Not blinding sampling timesObinoscopy 2018-08-19 22:20
- Blinding in Bioanalysis Obinoscopy 2018-08-19 21:37
- Not blinding sampling times Helmut 2018-08-19 19:06
- Blinding in Bioanalysis ElMaestro 2018-08-19 18:46
Ing. Helmut Schütz