## Use of lower bound for power of two combined TOST [Power / Sample Size]

Dear Ben,

nice to hear from you again.

» interesting observation. Thanks for pointing this out.

You are welcome.

» ...

» » Seems to me that the authors recommend to use the lower bound as criterion for setting the targetpower, i.e. if an overall power of 0.8 is aimed for, the powers for the two metrics have to be chosen such that the lower bound >= 0.8.

» Maybe I missed it but I don't see this statement explicitly. Can you point me to the direction?

You are correct that there is no statement explicitly. The wording of the whole paragraph is not that clear understandable, to say it politely.

Maybe I read to much into it. But the example

nice to hear from you again.

» interesting observation. Thanks for pointing this out.

You are welcome.

» ...

» » Seems to me that the authors recommend to use the lower bound as criterion for setting the targetpower, i.e. if an overall power of 0.8 is aimed for, the powers for the two metrics have to be chosen such that the lower bound >= 0.8.

» Maybe I missed it but I don't see this statement explicitly. Can you point me to the direction?

You are correct that there is no statement explicitly. The wording of the whole paragraph is not that clear understandable, to say it politely.

Maybe I read to much into it. But the example

*"if power for Cmax is 0.90, and for AUC 0.95, the resulting overall study power is at least 0.9 + 0.95 - 1 = 0.85"*smells for me in that direction.—

Regards,

Detlew

Regards,

Detlew

### Complete thread:

- Lower bound for power of two combined TOST? d_labes 2018-07-25 10:40
- Lower bound for power of two combined TOST? ElMaestro 2018-07-25 12:07
- Lower bound for power of two combined TOST? d_labes 2018-07-25 14:46
- Appendix D mittyri 2018-07-26 00:07
- Appendix D d_labes 2018-07-26 13:41

- Appendix D mittyri 2018-07-26 00:07

- Lower bound for power of two combined TOST? d_labes 2018-07-25 14:46
- Use of lower bound for power of two combined TOST d_labes 2018-07-26 14:29
- Use of lower bound for power of two combined TOST Ben 2018-08-06 18:11
- Use of lower bound for power of two combined TOSTd_labes 2018-08-07 11:50

- Use of lower bound for power of two combined TOST Ben 2018-08-06 18:11

- Lower bound for power of two combined TOST? ElMaestro 2018-07-25 12:07