Dose-proportionality versus dose-linearity [PK / PD]

posted by Ben – 2018-08-06 19:39 (1006 d 13:32 ago) – Posting: # 19155
Views: 4,261

Dear martin,

I must admit I am a bit relieved to see that apparently there is some general confusion around this topic ;-).

Your example 1. makes sense to me. Do you have an example for 2.?

Maybe we can go one step back and clarify nomenclature. When you talk about "linear PK" you apparently do not mean the same thing as dose proportionality. Are you using "linear PK" interchangebly to "dose linearity"? I see all kinds of definitions, some define linear PK to be dose proportionality, some don't. Of course it always depends on the underlying model (how many compartments?)... Is there a general definition of the three terms?


Complete thread:

 Admin contact
21,445 posts in 4,482 threads, 1,510 registered users;
online 8 (0 registered, 8 guests [including 4 identified bots]).
Forum time: Sunday 09:12 CEST (Europe/Vienna)

It is better to know some of the questions
than all of the answers.    James Thurber

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz