Bioequivalence and Bioavailability Forum 09:45 CEST

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Dose-proportionality versus dose-linearity [PK / PD]

posted by Ben - 2018-08-06 19:39  - Posting: # 19155
Views: 1,692

Dear martin,

I must admit I am a bit relieved to see that apparently there is some general confusion around this topic ;-).

Your example 1. makes sense to me. Do you have an example for 2.?

Maybe we can go one step back and clarify nomenclature. When you talk about "linear PK" you apparently do not mean the same thing as dose proportionality. Are you using "linear PK" interchangebly to "dose linearity"? I see all kinds of definitions, some define linear PK to be dose proportionality, some don't. Of course it always depends on the underlying model (how many compartments?)... Is there a general definition of the three terms?

Thanks
Ben.

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,782 posts in 4,002 threads, 1,256 registered users;
online 11 (0 registered, 11 guests [including 8 identified bots]).

[…] our greatest mistake would be to forget that data
is used for serious decisions in the very real world,
and bad information causes suffering and death.    Ben Goldacre

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed