the results of sample size based on PowerTOST [Software]
Hi libaiyi,
I am still somewhat baffled.
You have different SE's for the three comparisons, possibly suggesting that you are employing an EMA-style BE evaluation?
Anyways, if you are going for a 222BE design, then you can look at your MSE from the ANOVAs (plural, right?), convert them to CVs via CV=sqrt(exp(MSE)-1) and you have a decent variability estimate to plug in for any crossover design with or without scaling.
Your best point estimate is exp(-.2088)~0.81 with upper limit ~0.88, for the T-S pair. The others appear worse. I'd personally think twice, but I am widely known as a backward cowardly chicken.
Note, the opinion above implies logarithms and standard BE thinking.
Edit: Congratulations to your post № 1,500! [Helmut]
❝ The design here is a three-period six-sequence William design. I just wondering when the study design is replicated, dose the power calculation method the same as what used in simple 2 by 2 cross over design? Thank you so much!
I am still somewhat baffled.
You have different SE's for the three comparisons, possibly suggesting that you are employing an EMA-style BE evaluation?
Anyways, if you are going for a 222BE design, then you can look at your MSE from the ANOVAs (plural, right?), convert them to CVs via CV=sqrt(exp(MSE)-1) and you have a decent variability estimate to plug in for any crossover design with or without scaling.
Your best point estimate is exp(-.2088)~0.81 with upper limit ~0.88, for the T-S pair. The others appear worse. I'd personally think twice, but I am widely known as a backward cowardly chicken.
Note, the opinion above implies logarithms and standard BE thinking.
Edit: Congratulations to your post № 1,500! [Helmut]
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- the results of sample size based on PowerTOST libaiyi 2018-07-27 05:34 [Software]
- sample size based on PowerTOST: total number of subjects Helmut 2018-07-27 11:24
- sample size based on PowerTOST: total number of subjects libaiyi 2018-07-27 11:49
- the results of sample size based on PowerTOST ElMaestro 2018-07-27 19:57
- Design with not estimable contrast d_labes 2018-07-28 12:43
- the results of sample size based on PowerTOST libaiyi 2018-07-31 04:13
- the results of sample size based on PowerTOSTElMaestro 2018-07-31 11:07
- sample size based on PowerTOST: total number of subjects Helmut 2018-07-27 11:24