the results of sample size based on PowerTOST [Software]

posted by ElMaestro  – Belgium?, 2018-07-31 11:07 (781 d 00:58 ago) – Posting: # 19119
Views: 4,158

Hi libaiyi,

» The design here is a three-period six-sequence William design. I just wondering when the study design is replicated, dose the power calculation method the same as what used in simple 2 by 2 cross over design? Thank you so much!:lol:

I am still somewhat baffled.
You have different SE's for the three comparisons, possibly suggesting that you are employing an EMA-style BE evaluation?

Anyways, if you are going for a 222BE design, then you can look at your MSE from the ANOVAs (plural, right?), convert them to CVs via CV=sqrt(exp(MSE)-1) and you have a decent variability estimate to plug in for any crossover design with or without scaling.

Your best point estimate is exp(-.2088)~0.81 with upper limit ~0.88, for the T-S pair. The others appear worse. I'd personally think twice, but I am widely known as a backward cowardly chicken.


Note, the opinion above implies logarithms and standard BE thinking.


Edit: Congratulations to your post № 1,500! [Helmut]

I could be wrong, but...

Best regards,
ElMaestro

R's base package has 274 reserved words and operators, along with 1761 functions. I can use 18 of them (about 14 of them properly). I believe this makes me the Donald Trump of programming.

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