the results of sample size based on PowerTOST [Software]

posted by ElMaestro  – Belgium?, 2018-07-31 11:07 (853 d 21:11 ago) – Posting: # 19119
Views: 4,277

Hi libaiyi,

» The design here is a three-period six-sequence William design. I just wondering when the study design is replicated, dose the power calculation method the same as what used in simple 2 by 2 cross over design? Thank you so much!:lol:

I am still somewhat baffled.
You have different SE's for the three comparisons, possibly suggesting that you are employing an EMA-style BE evaluation?

Anyways, if you are going for a 222BE design, then you can look at your MSE from the ANOVAs (plural, right?), convert them to CVs via CV=sqrt(exp(MSE)-1) and you have a decent variability estimate to plug in for any crossover design with or without scaling.

Your best point estimate is exp(-.2088)~0.81 with upper limit ~0.88, for the T-S pair. The others appear worse. I'd personally think twice, but I am widely known as a backward cowardly chicken.


Note, the opinion above implies logarithms and standard BE thinking.


Edit: Congratulations to your post № 1,500! [Helmut]

I could be wrong, but...

Best regards,
ElMaestro

No, of course you do not need to audit your CRO if it was inspected in 1968 by the agency of Crabongostan.

Complete thread:

Activity
 Admin contact
21,224 posts in 4,427 threads, 1,481 registered users;
online 4 (0 registered, 4 guests [including 3 identified bots]).
Forum time: Tuesday 07:19 CET (Europe/Vienna)

The fundamental cause of trouble in the world today is
that the stupid are cocksure
while the intelligent are full of doubt.    Bertrand Russell

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5