Bioequivalence and Bioavailability Forum

❝ ❝ The ratio in your table is not a geometric mean ratio and is therefore rightly not labelled GMR. It is a ratio of LSMEAN, not of geometric means. It makes no difference if your study is balanced (i.e. same number of subjects with sequence TR and sequence RT, in which case the LSMEAN is equal to the geometric mean), but if you have a drop-out and your study gets unbalanced you will get some differences.

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❝ See this post for an example of unbalanced sequences and especially the PS.

Hi Helmut,

From your experience, do you recommend showing the geometric means along with the adjusted geometric means (from ls means) and the ratio from the adjusted in a single table? Or it does not make sense to even include the geometric means. My initial thought it would be good to include both just to see if the adjustments from the model. But it may cause confusion and may not be worth it.

Thanks,
Russel