## Lower bound for power of two combined TOST? [Power / Sample Size]

Hi d_labes,

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Surely that's either wrong or an approximation that has some validity within a set of strict conditions. I have not read that work or reference 918, but it looks outright wrong.

With that equation power could become negative, go figure.

By the way, the term pooled in the first sentence is also weird. The variances estimates for Cmax and AUCt are not "pooled", but I think they meant that the pool is just the dichotomous set of two variances.

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*Power >= PAUC + PCmax - (2 - 1)*

*where PAUC is the estimate of power for AUC and PCmax is the estimate of power for Cmax.*Surely that's either wrong or an approximation that has some validity within a set of strict conditions. I have not read that work or reference 918, but it looks outright wrong.

With that equation power could become negative, go figure.

By the way, the term pooled in the first sentence is also weird. The variances estimates for Cmax and AUCt are not "pooled", but I think they meant that the pool is just the dichotomous set of two variances.

—

Pass or fail!

ElMaestro

Pass or fail!

ElMaestro

### Complete thread:

- Lower bound for power of two combined TOST? d_labes 2018-07-25 10:40
- Lower bound for power of two combined TOST?ElMaestro 2018-07-25 12:07
- Lower bound for power of two combined TOST? d_labes 2018-07-25 14:46
- Appendix D mittyri 2018-07-26 00:07
- Appendix D d_labes 2018-07-26 13:41

- Appendix D mittyri 2018-07-26 00:07

- Lower bound for power of two combined TOST? d_labes 2018-07-25 14:46
- Use of lower bound for power of two combined TOST d_labes 2018-07-26 14:29
- Use of lower bound for power of two combined TOST Ben 2018-08-06 18:11
- Use of lower bound for power of two combined TOST d_labes 2018-08-07 11:50

- Use of lower bound for power of two combined TOST Ben 2018-08-06 18:11

- Lower bound for power of two combined TOST?ElMaestro 2018-07-25 12:07