Bioequivalence and Bioavailability Forum

Geometric means and adjusted means (LSMs) [General Statistics]

posted by Helmut – Vienna, Austria, 2018-07-19 15:01 (2100 d 21:47 ago) – Posting: # 19083
Views: 5,524

Hi Elena,

extending what Ohlbe wrote…

❝ The ratio in your table is not a geometric mean ratio and is therefore rightly not labelled GMR. It is a ratio of LSMEAN, not of geometric means. It makes no difference if your study is balanced (i.e. same number of subjects with sequence TR and sequence RT, in which case the LSMEAN is equal to the geometric mean), but if you have a drop-out and your study gets unbalanced you will get some differences.

See this post for an example of unbalanced sequences and especially the PS.

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Complete thread:

Manipulations with PK data in BE analysis Elena777 2018-07-18 15:35
- Manipulations with PK data in BE analysis ElMaestro 2018-07-18 23:19
- Manipulations with PK data in BE analysis Ohlbe 2018-07-19 10:31
  - Geometric means and adjusted means (LSMs)Helmut 2018-07-19 13:01
    - Geometric means and adjusted means (LSMs) crdreyes 2018-07-25 17:21
      - Geometric means and adjusted means (LSMs) Helmut 2018-07-26 15:38

Geometric means and adjusted means (LSMs) [General Sta­tis­tics]

Complete thread:

Geometric means and adjusted means (LSMs) [General Statistics]