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RegisterManipulations with PK data in BE analysis [General Statistics]
Hi Elena777,
I did not sanity-check the figures but at a glance it looks all normal and consistant with a standard BE study outcome.
Re. "manipulations": Data is typically log-transformed and then fit with a normal linear model with the four standard factors. If you use WNL with default settings it will fit Subject as random. From the model fit comes a set of effects for the factors, which give rise to treatment LSMeans (on the log scale). These are then backtransformed to the normal scale.
I did not sanity-check the figures but at a glance it looks all normal and consistant with a standard BE study outcome.
Re. "manipulations": Data is typically log-transformed and then fit with a normal linear model with the four standard factors. If you use WNL with default settings it will fit Subject as random. From the model fit comes a set of effects for the factors, which give rise to treatment LSMeans (on the log scale). These are then backtransformed to the normal scale.
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Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Manipulations with PK data in BE analysis Elena777 2018-07-18 15:35 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Manipulations with PK data in BE analysisElMaestro 2018-07-18 23:19
- Manipulations with PK data in BE analysis Ohlbe 2018-07-19 10:31
- Geometric means and adjusted means (LSMs) Helmut 2018-07-19 13:01
- Geometric means and adjusted means (LSMs) crdreyes 2018-07-25 17:21
- Geometric means and adjusted means (LSMs) Helmut 2018-07-26 15:38
- Geometric means and adjusted means (LSMs) crdreyes 2018-07-25 17:21
- Geometric means and adjusted means (LSMs) Helmut 2018-07-19 13:01
Ing. Helmut Schütz