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RegisterManipulations with PK data in BE analysis [General Statistics]
Dear colleagues.
I would like to know how pharamcokinetic data is manipulated during statistical analysis. Specifically, I would like to know when we should perform ln transformation: we calculate Geom mean and then transform its value to ln value and do ANOVA or we transform each concentration Cmax to Ln-data and then calculate geom mean. Or maybe it is not relevant?
I also would like to know how GMR is usually presented in tables. Whether it is usually GMR of ln-transformed or non-transformed data? I provide the table below as an example and would like to know the origin of its values as I asked above.
![[image]](img/uploaded/image525.png)
I would like to know how pharamcokinetic data is manipulated during statistical analysis. Specifically, I would like to know when we should perform ln transformation: we calculate Geom mean and then transform its value to ln value and do ANOVA or we transform each concentration Cmax to Ln-data and then calculate geom mean. Or maybe it is not relevant?
I also would like to know how GMR is usually presented in tables. Whether it is usually GMR of ln-transformed or non-transformed data? I provide the table below as an example and would like to know the origin of its values as I asked above.
Complete thread:
- Manipulations with PK data in BE analysisElena777 2018-07-18 15:35
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Manipulations with PK data in BE analysis ElMaestro 2018-07-18 23:19
- Manipulations with PK data in BE analysis Ohlbe 2018-07-19 10:31
- Geometric means and adjusted means (LSMs) Helmut 2018-07-19 13:01
- Geometric means and adjusted means (LSMs) crdreyes 2018-07-25 17:21
- Geometric means and adjusted means (LSMs) Helmut 2018-07-26 15:38
- Geometric means and adjusted means (LSMs) crdreyes 2018-07-25 17:21
- Geometric means and adjusted means (LSMs) Helmut 2018-07-19 13:01
Ing. Helmut Schütz