Manipulations with PK data in BE analysis [General Sta­tis­tics]

posted by Elena777 – Belarus, 2018-07-18 15:35 (797 d 01:08 ago) – Posting: # 19079
Views: 4,128

Dear colleagues.

I would like to know how pharamcokinetic data is manipulated during statistical analysis. Specifically, I would like to know when we should perform ln transformation: we calculate Geom mean and then transform its value to ln value and do ANOVA or we transform each concentration Cmax to Ln-data and then calculate geom mean. Or maybe it is not relevant?
I also would like to know how GMR is usually presented in tables. Whether it is usually GMR of ln-transformed or non-transformed data? I provide the table below as an example and would like to know the origin of its values as I asked above.


Complete thread:

 Admin contact
21,071 posts in 4,393 threads, 1,466 registered users;
online 4 (1 registered, 3 guests [including 1 identified bots]).
Forum time: Tuesday 16:43 CEST (Europe/Vienna)

Everybody is a Bayesian.
It’s just that some know it, and some don’t.    Trivellore Raghunathan

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz