Manipulations with PK data in BE analysis [General Sta­tis­tics]

posted by Elena777 – Belarus, 2018-07-18 17:35 (2080 d 04:34 ago) – Posting: # 19079
Views: 6,082

Dear colleagues.

I would like to know how pharamcokinetic data is manipulated during statistical analysis. Specifically, I would like to know when we should perform ln transformation: we calculate Geom mean and then transform its value to ln value and do ANOVA or we transform each concentration Cmax to Ln-data and then calculate geom mean. Or maybe it is not relevant?
I also would like to know how GMR is usually presented in tables. Whether it is usually GMR of ln-transformed or non-transformed data? I provide the table below as an example and would like to know the origin of its values as I asked above.

[image]

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
72 visitors (0 registered, 72 guests [including 8 identified bots]).
Forum time: 21:09 CET (Europe/Vienna)

Nothing shows a lack of mathematical education more
than an overly precise calculation.    Carl Friedrich Gauß

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5