Bioequivalence and Bioavailability Forum • Validation of PhEq

Validation of PhEq_bootstrap [Software]

posted by Shuanghe – Spain, 2018-07-17 17:54 (2525 d 08:20 ago) – Posting: # 19077
Views: 21,022

Hi Helmut!

❝ Now for the bad news. There is one thing stupid in the software when it comes to validation (line 535 of the source Conv_to_learn1.pas):

RandSeed:=random(random(1000000))+random(random(1000000));

That means that the seed of the (pseudo)random number generator is always a random number itself. Therefore, it is impossible to reproduce runs. Try it: you will not get exactly my results.

What a coincidence! I was in a meeting recently with a regulatory agency and the issue of reproducibility came up since the agency couldn't reproduce the bootstrap f2 values we reported in the dossier. My first thought was the different seed number. I opened the source files one by one and searched words like random, seed, to get the line. :-D

❝ IMHO, that’s bad coding practice.

Indeed. End user should be able to specify the seed number to be able to reproduce the analysis. I always leave a variable for seed number in my SAS code for bootstrap of BE data.

—
All the best,
Shuanghe

Complete thread:

Validation of PhEq_bootstrap Helmut 2018-07-12 17:47 [Software]
- Validation of PhEq_bootstrap ElMaestro 2018-07-12 22:21
  - Validation of PhEq_bootstrap Helmut 2018-07-13 01:29
    - Validation of PhEq_bootstrap ElMaestro 2018-07-13 10:14
      - Validation of PhEq_bootstrap Helmut 2018-07-13 12:54
        
        Validation of PhEq_bootstrap ElMaestro 2018-07-13 14:28
- Validation of PhEq_bootstrapShuanghe 2018-07-17 15:54
- PhEq_bootstrap in R d_labes 2018-08-15 09:45
  - bootf2BCA v1.1 Helmut 2019-10-05 00:59
    - bootf2BCA v1.2: seed Helmut 2020-09-25 19:37
      - bootf2BCA v1.2: seed PTM139 2021-04-16 07:53
        
        Which packages, working directory? Helmut 2021-04-16 10:50
        
        Which packages, working directory? PTM139 2021-04-27 13:02
      - bootf2BCA v1.2: seed Rayhope 2022-03-28 14:35
        
        bootf2BCA v1.3 Helmut 2022-03-28 14:48
        
        bootf2BCA v1.3 Rayhope 2022-03-30 06:34
    - bootf2BCA v1.1 Flam 2023-06-21 03:41
      - bootf2BCA v1.3.1 (current since 2022-06-25) Helmut 2023-06-23 13:47
        
        bootf2BCA v1.3.1 (current since 2022-06-25) Flam 2023-06-26 23:16
        
        Install required packages first Helmut 2023-06-27 11:47
- Validation of PhEq_bootstrap Rayhope 2021-07-29 08:49
  - Validation of PhEq_bootstrap Helmut 2021-08-02 18:12