BA/BE study - internal standard response variability [Bioanalytics]

posted by avinash – India, 2018-07-11 06:44 (930 d 14:22 ago) – Posting: # 19028
Views: 2,089

Dear Members,
In BA/BE study bio-analysis, is high internal standard response variability is a cause for LC-MS data batch rejection? (for example more than 20% of the unknown samples showing more than ±50% difference etc..)
General practice is only one scenario is considered for IS variation (±50% difference from the mean), is there any other scenario to be considered?
Trend analysis for Internal standard area response? Please comment.
Thanks & regards,
Avinash Jain M V

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