In-line filter Vs filter at end of sampling probe [Dissolution / BCS / IVIVC]

posted by Obinoscopy  – USA, 2018-07-09 15:15 (1075 d 12:29 ago) – Posting: # 19026
Views: 2,897

Hi guys,

Please I need an explanation on what is the difference between an in-line filter and filter at end of sampling probe.

I saw a dissolution methodology which stated thus:

"...tablet was placed into a dissolution medium and then 5ml of dissolution was withdrawn at the stipulated time and immediately filtered through a syringe filter."

This methodology was queried by seasoned regulators. They requested that the filters should be in-line or at the end of the sampling probe or both.

What do they mean by that statement? Isn't that syringe filter considered as an in-filter? What do they mean by filter at end of sampling probe? What's the difference between an in-line filter and a filter at end of sampling probe?

I will really appreciate an assistance with this puzzle.

Regards.

Scopy

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