Bioequivalence and Bioavailability Forum

Hi,ElMaestro

Sorry to reply in so many years. When I search for the reason of period effect, I found this post.

❝ ❝ Question. What can cause a period effect? Aside from carryover due to poor washout selection, and other unexplanable events (which I can't think of)?

❝

❝ Lots of speculation out there and regrettably very little actual substance.

❝ Carry-over in terms of pharmacological effect (e.g. some effect on the liver or intestine starting after dosing in period 1, still present in period 2). Anxiety, "this drug made me sick in period 1, hell, I am going to get sick in period 2, too" and John Doe will have diarhoea way before he event reports to the clinic but won't say anything out of fear of reduced compensation. And so forth. Don't waste your time medlining it.

I am a little confused that do you mean that carryover may cause carryover effect and period effect at the same time?

Thank you so much.