Log in
RegisterPilot or pivotal ? [General Statistics]
Hi Ohlbe,
» Sure, when you only have one test formulation. But when you hesitate between two ? Would you directly go for a pivotal where both test formulations would be compared to the reference, and then file whichever one passes ?
This is purely hypothetical for me. As far as I recall, I have not ever faced such a situation where two test formulations targeting the same authority were heads-on compared in a pivotal trial. I have faced it numerous times in pilot trials, but here the choice of formulation rarely is based on the CI but just on the observed GMR.
If I were in a situation, hypothetically, where I had one pivotal trial with two passing T formulations against a single, and I only needed one approval, then I am not sure what I would base my choice on. It could be cost of goods, or a risk-based assessment of the manufacturing bottlenecks for the two T formulations. Not sure, I have a feeling this would not be science-driven but Guy-in-Armani-suit-driven.
» Sure, when you only have one test formulation. But when you hesitate between two ? Would you directly go for a pivotal where both test formulations would be compared to the reference, and then file whichever one passes ?
This is purely hypothetical for me. As far as I recall, I have not ever faced such a situation where two test formulations targeting the same authority were heads-on compared in a pivotal trial. I have faced it numerous times in pilot trials, but here the choice of formulation rarely is based on the CI but just on the observed GMR.
If I were in a situation, hypothetically, where I had one pivotal trial with two passing T formulations against a single, and I only needed one approval, then I am not sure what I would base my choice on. It could be cost of goods, or a risk-based assessment of the manufacturing bottlenecks for the two T formulations. Not sure, I have a feeling this would not be science-driven but Guy-in-Armani-suit-driven.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Decision of confidence interval of three period BE study libaiyi 2018-06-26 12:00 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Two tests and one reference Helmut 2018-06-26 13:13
- Two tests and one reference Brus 2020-08-31 09:58
- Two tests and one reference ElMaestro 2020-08-31 10:23
- Two regions: No α adjustment Helmut 2020-08-31 10:26
- Two regions: No α adjustment Brus 2020-08-31 11:09
- Two regions: different populations Helmut 2020-08-31 11:26
- Two regions: No α adjustment Brus 2020-08-31 11:09
- Two tests and one reference Brus 2020-08-31 09:58
- Decision of confidence interval of three period BE study ElMaestro 2018-06-26 22:20
- Any of two tests and one reference Helmut 2018-06-27 00:33
- Any of two tests and one reference libaiyi 2018-06-27 08:25
- Hey wait a moment.... ElMaestro 2018-06-27 08:29
- Hey wait a moment.... Helmut 2018-06-27 11:45
- Pilot or pivotal ? Ohlbe 2018-06-27 12:14
- Pilot or pivotal ? ElMaestro 2018-06-27 13:01
- Pilot or pivotal ? Ohlbe 2018-06-27 14:13
- Pilot or pivotal ?ElMaestro 2018-06-27 14:48
- Pilot or pivotal ? Ohlbe 2018-06-27 15:43
- Pilot or pivotal ? ElMaestro 2018-06-27 22:13
- Pilot or pivotal ? Ohlbe 2018-06-27 15:43
- Pilot or pivotal ?ElMaestro 2018-06-27 14:48
- Pilot or pivotal ? Ohlbe 2018-06-27 14:13
- Pilot or pivotal ? jag009 2018-06-29 20:53
- Pilot or pivotal ? ElMaestro 2018-06-29 22:11
- Pilot or pivotal ? jag009 2018-07-03 17:38
- Pilot or pivotal ? ElMaestro 2018-06-29 22:11
- Pilot or pivotal ? ElMaestro 2018-06-27 13:01
- Hey, hey wait another moment.... d_labes 2018-06-28 19:48
- Hey, hey wait another moment.... Helmut 2018-07-03 17:22
- Old belives die hard d_labes 2018-07-04 13:28
- Hey, hey wait another moment.... Helmut 2018-07-03 17:22
- Pilot or pivotal ? Ohlbe 2018-06-27 12:14
- Hey wait a moment.... Helmut 2018-06-27 11:45
- Any of two tests and one reference Helmut 2018-06-27 00:33
- Two tests and one reference Helmut 2018-06-26 13:13
Ing. Helmut Schütz