Bioequivalence and Bioavailability Forum

Hey wait a moment.... [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2018-06-27 13:45 (2496 d 10:57 ago) – Posting: # 18974
Views: 15,210

Hi ElMaestro,

❝ […] I think I will need to put it into reverse here:

❝ Let us say both R1 and R2 are (truly) not BE…

❝

❝ We need that alpha correction. Sorry.

Haha, this time you answered a question not asked.

You want to get both T1 and T2 approved.

T1 = R ∧ T2 = R: ⇒ 95% CI

Clearly needs an adjustment because of the simultaneous tests and both T1 and T2 will be marketed.

You want to get either T1 or T2 approved.

T1 = R ∨ T2 = R: ⇒ 95% CI

In this case I argued for no adjustment (90% CI) in the past but nowadays I’m leaning towards an adjustment because which one will be marketed is part of a decision tree.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Decision of confidence interval of three period BE study libaiyi 2018-06-26 12:00 [General Sta­tis­tics] 
  • Two tests and one reference Helmut 2018-06-26 13:13
    • Two tests and one reference Brus 2020-08-31 09:58
      • Two tests and one reference ElMaestro 2020-08-31 10:23
      • Two regions: No α adjustment Helmut 2020-08-31 10:26
        • Two regions: No α adjustment Brus 2020-08-31 11:09
          • Two regions: different populations Helmut 2020-08-31 11:26
  • Decision of confidence interval of three period BE study ElMaestro 2018-06-26 22:20
    • Any of two tests and one reference Helmut 2018-06-27 00:33
      • Any of two tests and one reference libaiyi 2018-06-27 08:25
      • Hey wait a moment.... ElMaestro 2018-06-27 08:29
        • Hey wait a moment....Helmut 2018-06-27 11:45
          • Pilot or pivotal ? Ohlbe 2018-06-27 12:14
            • Pilot or pivotal ? ElMaestro 2018-06-27 13:01
              • Pilot or pivotal ? Ohlbe 2018-06-27 14:13
                • Pilot or pivotal ? ElMaestro 2018-06-27 14:48
                  • Pilot or pivotal ? Ohlbe 2018-06-27 15:43
                    • Pilot or pivotal ? ElMaestro 2018-06-27 22:13
            • Pilot or pivotal ? jag009 2018-06-29 20:53
              • Pilot or pivotal ? ElMaestro 2018-06-29 22:11
                • Pilot or pivotal ? jag009 2018-07-03 17:38
          • Hey, hey wait another moment.... d_labes 2018-06-28 19:48
            • Hey, hey wait another moment.... Helmut 2018-07-03 17:22
              • Old belives die hard d_labes 2018-07-04 13:28