Hey wait a moment.... [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2018-06-27 09:45 (845 d 16:49 ago) – Posting: # 18974
Views: 8,635

Hi ElMaestro,

» […] I think I will need to put it into reverse here:
» Let us say both R1 and R2 are (truly) not BE…
»
» We need that alpha correction. Sorry.

Haha, this time you answered a question not asked. ;-)

You want to get both T1 and T2 approved.

T1 = R T2 = R: ⇒ 95% CI

Clearly needs an adjustment because of the simultaneous tests and both T1 and T2 will be marketed.

You want to get either T1 or T2 approved.

T1 = R T2 = R: ⇒ 95% CI

In this case I argued for no adjustment (90% CI) in the past but nowadays I’m leaning towards an adjustment because which one will be marketed is part of a decision tree.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,162 posts in 4,410 threads, 1,476 registered users;
online 5 (0 registered, 5 guests [including 2 identified bots]).
Forum time: Tuesday 02:35 UTC (Europe/Vienna)

In theory, there is no difference between theory and practice.
But, in practice, there is.    Jan L.A. van de Snepscheut

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5