Bioequivalence and Bioavailability Forum

Any of two tests and one reference [General Statistics]

posted by Helmut – Vienna, Austria, 2018-06-27 02:33 (2123 d 00:02 ago) – Posting: # 18970
Views: 12,782

Hi ElMaestro,

❝ ❝ […] if the goal is to prove the equivalence of any two of them (T1 and R or T2 and R).

❝

❝ Due to the little word highlighted in red above I am fairly sure I would not apply any other alpha than 5%, meaning I would go with the usual 90% CIs. :-)

Good point – I missed that! In the past I did not adjust because only one will be marketed (i.e., the entire patient’s risk lies with this product). However, some regulatory statisticians (you know, coffee break chats) seem to be more strict because one gets two chances of passing. Too lazy to crawl the supplementary material of your paper about pilot studies: Is such a case covered?

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Helmut Schütz

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Complete thread:

Decision of confidence interval of three period BE study libaiyi 2018-06-26 12:00
- Two tests and one reference Helmut 2018-06-26 13:13
  - Two tests and one reference Brus 2020-08-31 09:58
    - Two tests and one reference ElMaestro 2020-08-31 10:23
    - Two regions: No α adjustment Helmut 2020-08-31 10:26
      - Two regions: No α adjustment Brus 2020-08-31 11:09
        
        Two regions: different populations Helmut 2020-08-31 11:26
- Decision of confidence interval of three period BE study ElMaestro 2018-06-26 22:20
  - Any of two tests and one referenceHelmut 2018-06-27 00:33
    - Any of two tests and one reference libaiyi 2018-06-27 08:25
    - Hey wait a moment.... ElMaestro 2018-06-27 08:29
      - Hey wait a moment.... Helmut 2018-06-27 11:45
        
        Pilot or pivotal ? Ohlbe 2018-06-27 12:14
        
        Pilot or pivotal ? ElMaestro 2018-06-27 13:01
        
        Pilot or pivotal ? Ohlbe 2018-06-27 14:13
        
        Pilot or pivotal ? ElMaestro 2018-06-27 14:48
        
        Pilot or pivotal ? Ohlbe 2018-06-27 15:43
        
        Pilot or pivotal ? ElMaestro 2018-06-27 22:13
        
        Pilot or pivotal ? jag009 2018-06-29 20:53
        
        Pilot or pivotal ? ElMaestro 2018-06-29 22:11
        
        Pilot or pivotal ? jag009 2018-07-03 17:38
        
        Hey, hey wait another moment.... d_labes 2018-06-28 19:48
        
        Hey, hey wait another moment.... Helmut 2018-07-03 17:22
        
        Old belives die hard d_labes 2018-07-04 13:28

Any of two tests and one reference [General Sta­tis­tics]

Complete thread:

Any of two tests and one reference [General Statistics]