Bioequivalence and Bioavailability Forum

Decision of confidence interval of three period BE study [General Sta­tis­tics]

posted by libaiyi – China, 2018-06-26 12:00 (1085 d 21:55 ago) – Posting: # 18964
Views: 11,446
(edited by Ohlbe on 2018-06-26 12:24)

Hi,all

I am curious of the confidence interval decision of three treatment, three sequences, cross over BE study as below, if the goal is to prove the equivalence of any two of them (T1 and R or T2 and R). Will the CI still determined as 95% or 90%?

Sequence/Period  1  2  3 
      1          R  T1 T2
      2          T1 T2 R 
      3          T2 R  T1

I also want to know how to select the suitable design between latin squares and William design when there exists three treatment, R T1 T2.

Thanks in advance.

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Edit: two posts merged. You can edit your message up to 24 hours after posting it [Ohlbe]

Complete thread:

• Decision of confidence interval of three period BE studylibaiyi 2018-06-26 12:00 [General Sta­tis­tics] 
  • Two tests and one reference Helmut 2018-06-26 13:13
    • Two tests and one reference Brus 2020-08-31 09:58
      • Two tests and one reference ElMaestro 2020-08-31 10:23
      • Two regions: No α adjustment Helmut 2020-08-31 10:26
        • Two regions: No α adjustment Brus 2020-08-31 11:09
          • Two regions: different populations Helmut 2020-08-31 11:26
  • Decision of confidence interval of three period BE study ElMaestro 2018-06-26 22:20
    • Any of two tests and one reference Helmut 2018-06-27 00:33
      • Any of two tests and one reference libaiyi 2018-06-27 08:25
      • Hey wait a moment.... ElMaestro 2018-06-27 08:29
        • Hey wait a moment.... Helmut 2018-06-27 11:45
          • Pilot or pivotal ? Ohlbe 2018-06-27 12:14
            • Pilot or pivotal ? ElMaestro 2018-06-27 13:01
              • Pilot or pivotal ? Ohlbe 2018-06-27 14:13
                • Pilot or pivotal ? ElMaestro 2018-06-27 14:48
                  • Pilot or pivotal ? Ohlbe 2018-06-27 15:43
                    • Pilot or pivotal ? ElMaestro 2018-06-27 22:13
            • Pilot or pivotal ? jag009 2018-06-29 20:53
              • Pilot or pivotal ? ElMaestro 2018-06-29 22:11
                • Pilot or pivotal ? jag009 2018-07-03 17:38
          • Hey, hey wait another moment.... d_labes 2018-06-28 19:48
            • Hey, hey wait another moment.... Helmut 2018-07-03 17:22
              • Old belives die hard d_labes 2018-07-04 13:28