Potency correction: Rather why than when [Regulatives / Guidelines]
Hi Hötzi,
You are on the right track. I think this was largely an answer to a question I didn't ask, and not answer to the question I asked. I believe I once again perhaps did not explain myself properly enough.
I will try and use your own language:
AUCT/AUCR=(fT/fR)(DT/DR)(CLR/CLT)
where we will assume CLT=CLR, so
AUCT/AUCR=(fT/fR)(DT/DR) or
(DR*AUCT) / (DT*AUCR) = fT/fR or
(DR/DT)*(AUCT/AUCR)=fT/fR
This multiplication by the dose ratio is essentially what the potency correction achieves. You can rearrange that also in another outright horrible fashion:
(AUCT/DT) / (AUCR/DR) = FT/FR
Ouch. Potency correction is the wonderful tool I can use to prove that 5x250 mg Schützomycin tablets are bioequivalent to 1x250 mg Schützomycin . Let us for the purpose of this discussion leave out non-linear kinetics etc.
❝ let’s consider the basics. We have a set of two equations
- AUCT = ƒT·DT/CLT
❝
- AUCR = ƒR·DR/CLR
You are on the right track. I think this was largely an answer to a question I didn't ask, and not answer to the question I asked. I believe I once again perhaps did not explain myself properly enough.
I will try and use your own language:
AUCT/AUCR=(fT/fR)(DT/DR)(CLR/CLT)
where we will assume CLT=CLR, so
AUCT/AUCR=(fT/fR)(DT/DR) or
(DR*AUCT) / (DT*AUCR) = fT/fR or
(DR/DT)*(AUCT/AUCR)=fT/fR
This multiplication by the dose ratio is essentially what the potency correction achieves. You can rearrange that also in another outright horrible fashion:
(AUCT/DT) / (AUCR/DR) = FT/FR
Ouch. Potency correction is the wonderful tool I can use to prove that 5x250 mg Schützomycin tablets are bioequivalent to 1x250 mg Schützomycin . Let us for the purpose of this discussion leave out non-linear kinetics etc.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Potency correction - I still don't get it ElMaestro 2018-06-23 10:14 [Regulatives / Guidelines]
- Potency correction - Only in exceptional cases d_labes 2018-06-23 18:04
- Potency correction - Only in exceptional cases ElMaestro 2018-06-23 19:55
- Potency correction: Rather why than when Helmut 2018-06-24 00:55
- Potency correction: Rather why than whenElMaestro 2018-06-25 10:22
- Potency correction: Upper limit? Helmut 2018-06-25 15:34
- Potency correction: Rather why than whenElMaestro 2018-06-25 10:22
- Potency correction - Example d_labes 2018-06-24 14:40
- Potency correction: Rather why than when Helmut 2018-06-24 00:55
- Potency correction - Only in exceptional cases ElMaestro 2018-06-23 19:55
- Potency correction - EAUnion opinion mittyri 2018-06-23 22:53
- Potency correction - example Ohlbe 2018-06-25 10:10
- Let me answer my own question ElMaestro 2018-06-25 18:24
- Someone, somebody - slightly OT d_labes 2018-06-25 19:49
- Potency correction - Only in exceptional cases d_labes 2018-06-23 18:04