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RegisterNo significance testing in BE [Nonparametrics]
posted by Helmut 
– Vienna, Austria, 2018-06-20 13:24 (2135 d 04:11 ago) – Posting: # 18928
Views: 8,110
Hi libaiyi,
no idea about SAS.
Phoenix:
My R-code:
Generally I prefer an exact test over an asymptotic one.
Significance testing is of historic interest in BE only (was abandoned decades ago). You should pre-specify an interval which you consider to be not relevant from a clinical perspective. For tmax of a pain-killer it might be just ±20 minutes but for a modified release product which is only used in steady state even a couple of hours. At the end assess whether the CI of the difference lies within the interval as usual.
no idea about SAS.
Phoenix:
Test T_stat p_value
Treatment|(SEQ1=SEQ2) 46 0.39727171My R-code:
Expectation : 52.5
Statistic : 46
Exact : Z = -0.84650388, p-value = 0.41491841
Asymptotic : Z = -0.84650388, p-value = 0.39727171❝ So, which p value should I take as the decision standard for the test?
Generally I prefer an exact test over an asymptotic one.
Significance testing is of historic interest in BE only (was abandoned decades ago). You should pre-specify an interval which you consider to be not relevant from a clinical perspective. For tmax of a pain-killer it might be just ±20 minutes but for a modified release product which is only used in steady state even a couple of hours. At the end assess whether the CI of the difference lies within the interval as usual.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Test statistic about Tmax libaiyi 2018-06-19 08:15 [Nonparametrics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Wilcoxon signed rank test Helmut 2018-06-19 11:54
- Wilcoxon-Mann-Whitney! d_labes 2018-06-19 13:25
- Wilcoxon-Mann-Whitney! Helmut 2018-06-19 16:38
- Wilcoxon-Mann-Whitney PMID d_labes 2018-06-19 17:10
- Wilcoxon-Mann-Whitney! Imph 2022-05-09 10:22
- Wilcoxon-Mann-Whitney! Helmut 2018-06-19 16:38
- choice of result libaiyi 2018-06-20 08:20
- No significance testing in BEHelmut 2018-06-20 11:24
- Wilcoxon-Mann-Whitney! d_labes 2018-06-19 13:25
- Wilcoxon signed rank test Helmut 2018-06-19 11:54
Ing. Helmut Schütz