Bioequivalence and Bioavailability Forum

Unlike the nonparametric confidence interval according to Steinijans and Diletti [1983], the non­parametric approach by Hauschke et al. [1990] is no longer limited by the assumption of equal period effects. Although, according to our vast experience, unequal period effects are extremely rare, they may result in a biased point estimate and an unnecessarily wide confidence interval if the procedure assuming equal period effects is applied incorrectly. To avoid this, the nonparametric procedure by Steinijans and Diletti [1983] should generally be replaced by that of Hauschke et al. [1990].