Within-subject variability: Property of the drug (& formulation) [General Statistics]
❝ 2. Some people claim that extreme standardization (BMI, …) will also help to reduce CVintra. I strongly doubt that since the between- and within-variance components are mutually independent.
I would assume that volunteers with very constant everyday habits, including sleeping, diet (!), GI-transit time etc. etc. have reduced intraindivdual variability. Maybe do a BE-study in a monastery as proof-of-concept?

For your in vitro dissolution testing you don't mix within one experiment (!) basket and paddle employing various rotation speeds, use flasks of different volumes, different buffers, temperatures etc. pp. to reduce variability, or? So why shouldn't high standardization work with your in vivo dissolution system, too?
—
Kindest regards, nobody
Kindest regards, nobody
Complete thread:
- how to calculate MSEw and MSEb verstc 2018-06-12 02:23 [General Statistics]
- Get software! Helmut 2018-06-12 16:54
- Get software! verstc 2018-06-17 14:55
- Within-subject variability: Property of the drug (& formulation) Helmut 2018-06-17 16:10
- Within-subject variability: Property of the drug (& formulation)nobody 2018-06-19 10:20
- Within-subject variability: Property of the drug (& formulation) Helmut 2018-06-17 16:10
- Get software! verstc 2018-06-17 14:55
- Get software! Helmut 2018-06-12 16:54