Bad weather? [Two-Stage / GS Designs]

posted by Helmut Homepage – Vienna, Austria, 2018-06-13 19:23  – Posting: # 18901
Views: 6,382

Dear Detlew,

» If I see it correctly…

You do.

» … that's called in Maurer et al. "futility rule can be applied in a nonbinding manner, ie, it can be used as guidance but must not necessarily be followed." (page 19, bottom)

Sounds to me like the statement of the FDA’s guidances “Contains Nonbinding Recommendations” or a similar one in the protocols of European Scientific Advices. :cool:

» How to obtain a sample size number for the second stage if we want to do so?

Introducing fuzzy logic to the AlGore Rhythm? Stop if it looks really terrible or continue if the weather is not that bad.*



Cheers,
Helmut Schütz
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