Impact of pooled variance (bias, CI) [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2018-06-13 17:02 (2500 d 14:58 ago) – Posting: # 18898
Views: 32,009

Hi Irene,

❝ Thank you for your explanation.


You are welcome. A picture tells more than a thousand words (AUC only). ;-)

[image]


The PE and its CI of T/R are similar. The small bias is caused by the fact that the average PE of S/R and T/S (\(\sqrt{141.09\times83.12}\)) is close to the T/R with 116.05. The other comparisons show negative biases. The CI of S/R is narrower in the pooled model and the CI of T/S is wider.
We don’t want to go there.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,709 registered users;
29 visitors (0 registered, 29 guests [including 7 identified bots]).
Forum time: 08:01 CEST (Europe/Vienna)

Do not worry about your difficulties in mathematics.
I can assure you mine are still greater.    Albert Einstein

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5