Bioequivalence and Bioavailability Forum

Impact of pooled variance (bias, CI) [Design Issues]

posted by Helmut  – Vienna, Austria, 2018-06-13 15:02 (865 d 01:13 ago) – Posting: # 18898
Views: 11,944

Hi Irene,

» Thank you for your explanation.

You are welcome. A picture tells more than a thousand words (AUC only). 

The PE and its CI of T/R are similar. The small bias is caused by the fact that the average PE of S/R and T/S (\(\sqrt{141.09\times83.12}\)) is close to the T/R with 116.05. The other comparisons show negative biases. The CI of S/R is narrower in the pooled model and the CI of T/S is wider.
We don’t want to go there.

—
Dif-tor heh smusma 🖖
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:

• Three-way crossover BABE Studies acfalcao 2007-09-16 22:34 [Design Issues] 
  • Three-way crossover example data set Helmut 2007-09-17 20:47
    • Three-way crossover example data set acfalcao 2007-09-17 23:02
      • Three-way crossover example data set Helmut 2007-09-18 12:47
        • Three-way crossover (WinNonlin) Nirali 2007-09-21 06:49
          • Three-way crossover (WinNonlin) Helmut 2007-09-21 13:04
            • Three-way crossover (WinNonlin) Nirali 2007-09-25 08:05
              • Three-way crossover (WinNonlin) Helmut 2007-09-25 13:15
        • Three-way crossover example data set Irene_I 2018-06-07 11:09
          • Three-way crossover example data set Helmut 2018-06-07 13:04
            • Three-way crossover example data set Irene_I 2018-06-08 11:09
            • Three-way crossover example data set Irene_I 2018-06-12 09:21
              • Leave-One-Out (IBD) Helmut 2018-06-12 12:42
                • Leave-One-Out (IBD) Irene_I 2018-06-13 05:02
                  • Impact of pooled variance (bias, CI)Helmut 2018-06-13 15:02
                • carry (over?) d_labes 2018-06-13 15:31
    • Pseudo-periods ElAlumno 2019-03-14 23:40
      • Pseudo-periods Helmut 2019-03-15 00:47
        • Two‐at‐a‐Time analysis in R ElAlumno 2019-03-22 21:59
          • fixed & mixed (dammit!) and a request to SASians Helmut 2019-03-23 01:03
            • Pooled vs IBD T-R in SAS from non-SASian mittyri 2019-03-23 23:13
              • Pooled vs IBD T-R in SAS from non-SASian Helmut 2019-03-23 23:36
            • mixed in R mittyri 2019-03-23 23:50
              • mixed in R (EMA B ≠ FDA) Helmut 2019-03-24 01:23