Bioequivalence and Bioavailability Forum

Impact of pooled variance (bias, CI) [Design Issues]

posted by Helmut  – Vienna, Austria, 2018-06-13 15:02 (1222 d 12:57 ago) – Posting: # 18898
Views: 15,802

Hi Irene,

» Thank you for your explanation.

You are welcome. A picture tells more than a thousand words (AUC only). 

The PE and its CI of T/R are similar. The small bias is caused by the fact that the average PE of S/R and T/S (\(\sqrt{141.09\times83.12}\)) is close to the T/R with 116.05. The other comparisons show negative biases. The CI of S/R is narrower in the pooled model and the CI of T/S is wider.
We don’t want to go there.

—
Dif-tor heh smusma 🖖
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
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