Impact of pooled variance (bias, CI) [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2018-06-13 15:02 (865 d 01:13 ago) – Posting: # 18898
Views: 11,944

Hi Irene,

» Thank you for your explanation.

You are welcome. A picture tells more than a thousand words (AUC only). ;-)

[image]


The PE and its CI of T/R are similar. The small bias is caused by the fact that the average PE of S/R and T/S (\(\sqrt{141.09\times83.12}\)) is close to the T/R with 116.05. The other comparisons show negative biases. The CI of S/R is narrower in the pooled model and the CI of T/S is wider.
We don’t want to go there.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,179 posts in 4,414 threads, 1,474 registered users;
online 4 (0 registered, 4 guests [including 4 identified bots]).
Forum time: Sunday 15:16 CET (Europe/Vienna)

Mediocrity knows nothing higher than itself,
but talent instantly recognizes genius.    Arthur Conan Doyle

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5