Get software! [General Statistics]
Hi Shawn,
Welcome to the club!
Thanks for not mentioning the lousy partial replicate (TRR|RTR|RRT).
Do you want to calculate it manually (paper, pencil, brain)? A nice morning exercise as long as you have only fixed effects in the model (ANOVA).*
If you are interested in full-blown mixed-effects models (e.g., the FDA’s or the CFDA’s for reference-scaling), forget it. This would require restricted maximum likelihood estimation, which is – practically – impossible without software.
Given all that, get suitable software, validate it, and be happy. The residual mean squares are part of the standard output (example of a 2×2 design).
❝ I am a fresher to BE analysis.
Welcome to the club!
❝ […] how to calculate the MSE_w and MSE_B for 2 X 2 crossover design and fully replicated design (TRT|RTR or TRTR|RTRT).
Thanks for not mentioning the lousy partial replicate (TRR|RTR|RRT).

❝ Could anyone tell me the detail of calculation for these different designs?
Do you want to calculate it manually (paper, pencil, brain)? A nice morning exercise as long as you have only fixed effects in the model (ANOVA).*
If you are interested in full-blown mixed-effects models (e.g., the FDA’s or the CFDA’s for reference-scaling), forget it. This would require restricted maximum likelihood estimation, which is – practically – impossible without software.
Given all that, get suitable software, validate it, and be happy. The residual mean squares are part of the standard output (example of a 2×2 design).
- Chow S-C, Liu J-p. Design and Analysis of Bioavailability and Bioequivalence Studies.
Boca Raton: CRC Press; 3rd edition 2009. ISBN: 978-1-58488-668-6.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- how to calculate MSEw and MSEb verstc 2018-06-12 02:23 [General Statistics]
- Get software!Helmut 2018-06-12 16:54
- Get software! verstc 2018-06-17 14:55
- Within-subject variability: Property of the drug (& formulation) Helmut 2018-06-17 16:10
- Within-subject variability: Property of the drug (& formulation) nobody 2018-06-19 10:20
- Within-subject variability: Property of the drug (& formulation) Helmut 2018-06-17 16:10
- Get software! verstc 2018-06-17 14:55
- Get software!Helmut 2018-06-12 16:54