a bug in interim.tsd.in()? [Two-Stage / GS Designs]

posted by mittyri – Russia, 2018-06-11 23:27  – Posting: # 18884
Views: 7,433

Dear Ben,

Thank you for explanations!
As I mentioned above, I was not aware that Maurer method is not just another set of alphas. After reading the manuscript I understood the concept.
I tried to simulate some data to show the approach of safety net with inverse normal vs fixed (Helmut is right, it is very popular in Russia last days as my colleagues said; of course the Sponsors are using Potvin C :-D)

But my loop was interrupted:
interim.tsd.in(GMR1=0.89, CV1=0.2575165, n1=38)
Error in tval[, 1] : incorrect number of dimensions
In addition: Warning messages:
1: In qnorm(p2) : NaNs produced
2: In min(df) : no non-missing arguments to min; returning Inf


What is going on here?
I thought the problem with GMR1<0.9, tried to add some condition to omit the replicates with GMR1<0.9, but even that case got the same error for some replicates.

Kind regards,
Mittyri

Complete thread:

Activity
 Admin contact
20,470 posts in 4,300 threads, 1,415 registered users;
online 14 (0 registered, 14 guests [including 5 identified bots]).
Forum time (Europe/Vienna): 11:14 CEST

We should not speak so that it is possible
for the audience to understand us,
but so that it is impossible
for them to misunderstand us.    Quintilian

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5