Rapid dissolution paradox [Dissolution / BCS / IVIVC]

posted by Melkor – Greece, 2018-06-03 13:02 (2594 d 03:50 ago) – Posting: # 18843
Views: 2,480

Greetings!

I have been facing a paradox with a specific solid dosage formula with rapid dissolution rate. When conducting the dissolution test at three conventional pH the %release of the test product at 4.5 pH lowers upon reaching the max %release in 5 mins and then reaches a plateau. This does not happen for the RLD at the same pH and the performance for both product at all remaining pH is similar.

I have faced this before with rapid dissolution products but i would really like to have a scientific explanation on this.

Any ideas?

Thank you

Edit: Category changed; see also this post #1. [Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
23,428 posts in 4,929 threads, 1,682 registered users;
50 visitors (0 registered, 50 guests [including 9 identified bots]).
Forum time: 16:53 CEST (Europe/Vienna)

To know that we know what we know,
and to know that we do not know what we do not know,
that is true knowledge.    Nicolaus Copernicus

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5