Relevant: The PK metric with highest CV [Power / Sample Size]
Hi libaiyi,
AUC and Cmax are (highly?) correlated as well.
If you think about sample size estimation I would go a step further and consider only the PK metric with the highest variability, which generally* is the one of Cmax (see [msg]this thread[/msg], linked other posts, and references). You could use function
❝ I want to ask about power calculation. In BE, Cmax, AUCt, and AUCinf are all needed for power consideration. […] But AUCinf and AUCt are highly correlated,
AUC and Cmax are (highly?) correlated as well.
❝ […] so could I […] only consider about AUCt and Cmax for the power setting?
If you think about sample size estimation I would go a step further and consider only the PK metric with the highest variability, which generally* is the one of Cmax (see [msg]this thread[/msg], linked other posts, and references). You could use function
power.2TOST()
of the R-package PowerTOST
to explore various correlations (ρ). This issue is a little bit academic because ρ is rarely known.- An early truncated partial AUC can be highly variable as well.
—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Power decrease for the highly correlation of AUCt and AUCinf libaiyi 2018-05-23 08:40 [Power / Sample Size]
- Relevant: The PK metric with highest CVHelmut 2018-05-23 10:40
- Relevant: The PK metric with highest CV libaiyi 2018-05-24 10:02
- Power of 2 independent TOSTs ≈ 2 simultaneous TOSTs with ρ=0 Helmut 2018-05-24 12:54
- Power of 2 independent TOSTs ≈ 2 simultaneous TOSTs with ρ=0 libaiyi 2018-05-30 03:24
- Power of 2 independent TOSTs ≈ 2 simultaneous TOSTs with ρ=0 Helmut 2018-05-24 12:54
- Relevant: The PK metric with highest CV libaiyi 2018-05-24 10:02
- Relevant: The PK metric with highest CVHelmut 2018-05-23 10:40