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RegisterPower decrease for the highly correlation of AUCt and AUCinf [Power / Sample Size]
Hi, all
I want to ask about power calculation. In BE, Cmax, AUCt, and AUCinf are all needed for power consideration. And the power for each one need to be bigger than overall power for the accumulation of power. But AUCinf and AUCt are highly correlated, so could I decrease the individual power and only consider about AUCt and Cmax for the power setting?
Thanks in advance.
I want to ask about power calculation. In BE, Cmax, AUCt, and AUCinf are all needed for power consideration. And the power for each one need to be bigger than overall power for the accumulation of power. But AUCinf and AUCt are highly correlated, so could I decrease the individual power and only consider about AUCt and Cmax for the power setting?
Thanks in advance.
Complete thread:
- Power decrease for the highly correlation of AUCt and AUCinflibaiyi 2018-05-23 08:40 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Relevant: The PK metric with highest CV Helmut 2018-05-23 10:40
- Relevant: The PK metric with highest CV libaiyi 2018-05-24 10:02
- Power of 2 independent TOSTs ≈ 2 simultaneous TOSTs with ρ=0 Helmut 2018-05-24 12:54
- Power of 2 independent TOSTs ≈ 2 simultaneous TOSTs with ρ=0 libaiyi 2018-05-30 03:24
- Power of 2 independent TOSTs ≈ 2 simultaneous TOSTs with ρ=0 Helmut 2018-05-24 12:54
- Relevant: The PK metric with highest CV libaiyi 2018-05-24 10:02
- Relevant: The PK metric with highest CV Helmut 2018-05-23 10:40
Ing. Helmut Schütz