Bioequivalence and Bioavailability Forum • Enhancement from concomitant medications

Enhancement from concomitant medications [Bioanalytics]

posted by Ohlbe – France, 2018-05-02 13:36 (2179 d 17:29 ago) – Posting: # 18747
Views: 3,598

Dear ElMaestro,

❝ interference like ion enhancement has never been seen

It has. There may be some more recent publication, but I have this one in my archives:

Rachael Leverence, Michael J. Avery, Olga Kavetskaia, Honggang Bi, Cornelis E. C. A. Hop and Arkady I. Gusev
Signal suppression/enhancement in HPLC-ESI-MS/MS from concomitant medications
Biomed. Chromatogr. 21: 1143–1150 (2007)
doi:10.1002/bmc.863

—
Regards
Ohlbe

Complete thread:

Concomitant medications experiment in method validation chandru 2018-02-14 07:31
- Concomitant medications experiment in method validation Obinoscopy 2018-05-02 04:05
- Concomitant medications experiment in method validation ElMaestro 2018-05-02 09:25
  - Enhancement from concomitant medicationsOhlbe 2018-05-02 11:36
    - Enhancement from concomitant medications ElMaestro 2018-05-02 12:23
      - Enhancement from concomitant medications Ohlbe 2018-05-02 12:34
        
        US FDA guidance chandru 2018-05-27 21:41