Bioequivalence and Bioavailability Forum • Selection of w and w*

Selection of w and w* [Two-Stage / GS Designs]

posted by d_labes – Berlin, Germany, 2018-04-26 20:02 (1487 d 13:45 ago) – Posting: # 18734
Views: 14,575

Dear Helmut,

» ...
» Using the median of n.tot to define the weights from the sim’s was a – maybe too naïve – attempt. Other suggestions? Some regulatory statisticians prefer the first stage in a TSD to be like in a fixed sample design. For some combinations of n₁/CV in my grid this will be ≤ the median of n.tot. In other words, I’m not too optimistic but rather too pessimistic. Now what?

As I already said, DUNO really.

» Example: CV 0.1, GMR 0.95, target power 0.80. Fixed sample design’s n 8 (n₁ ⇒ 12 acc. to GLs). n.mean and median of n.tot 12 with the default weights (0.5, 0.25). Even the 95% percentile of n.tot is 12.
» :confused:

If you were pesssimistic, so in the spirit of the MCT ist would be wise to choose the second pair of weights with decreased value. Or do I err here ("real" n2 lower than the pessimistic)?
If I'm right, possible values could be:
w=0.999, w*=0.5 (or something like that value)

Or we stay for that extremal case with the standard combination test?

But to state it again: For me it is a mystery how to choose the weights.
But I think it doesn't make so much difference if we are not totally wrong with our choosen weights.
As far as I have seen so far for a small number of examples: The power is influenced only to a "minor" extent. The TIE is controlled, whatsoever weights we choose.

—
Regards,

Detlew

Complete thread:

Finally: Exact TSD methods for 2×2 crossover designs Helmut 2018-04-21 17:17 [Two-Stage / GS Designs]
- Exact TSD methods: Example Helmut 2018-04-21 20:33
- Finally: Exact TSD methods for 2×2 crossover designs ElMaestro 2018-04-21 20:49
  - Flow chart (without details) Helmut 2018-04-21 21:41
    - naive questions regarding new functions in Power2Stage mittyri 2018-04-28 15:54
      - Some answers Helmut 2018-04-28 17:29
      - Some more "answers" d_labes 2018-04-29 21:11
        
        clarification regarding user Power2Stage guides mittyri 2018-04-30 13:41
- Technicality: Weigths for the inverse normal approach d_labes 2018-04-25 14:19
  - Selection of w and w* Helmut 2018-04-26 09:51
    - Selection of w and w*d_labes 2018-04-26 20:02
    - Now what? w & w* examples d_labes 2018-05-09 13:53
      - Now what? w & w* examples Ben 2018-06-10 20:12
        
        Now what? w & w* examples Helmut 2018-06-11 13:57
        
        Now what? w & w* examples Ben 2018-06-12 19:14
        
        a bug in interim.tsd.in()? mittyri 2018-06-11 23:27
        
        a bug in interim.tsd.in()? Ben 2018-06-12 19:32
        
        Nonbinding futility rule d_labes 2018-06-13 16:59
        
        Bad weather? Helmut 2018-06-13 19:23
        
        NLYW? d_labes 2018-06-14 10:18
        
        Nonbinding futility rule Ben 2018-06-13 20:26
        
        Nonbinding futility rule d_labes 2018-06-14 10:47
        
        Nonbinding futility rule Ben 2018-06-15 17:58
        
        Binding / Nonbinding futility rule - alpha control d_labes 2018-06-16 19:42
        
        Binding / Nonbinding futility rule - alpha control Ben 2019-03-30 09:52