Zero Sample Preparation [Bioanalytics]

posted by Ohlbe – France, 2018-04-20 16:21 (1580 d 01:41 ago) – Posting: # 18711
Views: 2,749

Dear Scopy,

» Oops, sorry a typo on my end. I meant to write QC and not BC

OK, then I know what it is :-)

» So my follow up question is this: What's the compositional or structural difference between a CC sample and BC sample.

None. Both are blank matrix spiked with known concentrations of analyte, then with IS when they are processed. The concentrations of the CC samples are established based on the expected range of concentrations to be measured; the concentrations of the QC samples are derived from that (LQC # 3 times the LLOQ, HQC at least 75 % of the ULOQ, MQC somewhere mid-range - the EMA guideline says 30-50 % of the range).


Complete thread:

UA Flag
 Admin contact
22,305 posts in 4,668 threads, 1,587 registered users;
online 14 (1 registered, 13 guests [including 7 identified bots]).
Forum time: Wednesday 18:02 CEST (Europe/Vienna)

There is no point in being precise when you don’t know
what you’re talking about.    attributed to John Tukey

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz