Bioequivalence and Bioavailability Forum

This theorem is used for calculation of confidence intervals for a ratio of expected means while assuming a normal distribution.

For concentration-related characteristics, a lognormal distribution is assumed in BA/BE studies. Hence, there is no need to apply Fieller's Theorem.

Please note that the application of this theorem in clinical trials is fully described in:
Hauschke D, Steinijans VW, Pigeot I
Bioequivalence: Methods and Applications, Statistics in Practice
John Wiley, Chichester (2007)

Kind regards
Dieter

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Prof. Dr. Dieter Hauschke
Institute of Medical Biometry
and Medical Informatics
University Medical Center Freiburg
Stefan-Meier-Str. 26
D-79104 Freiburg
phone: +49 (0)761 203 6665
fax: +49 (0)761 203 6680
http://www.imbi.uni-freiburg.de