What is clinically relevant? [Design Issues]

posted by nobody – 2018-04-05 10:04 (1595 d 08:56 ago) – Posting: # 18643
Views: 5,148

Hi Felix Austria!

Yeah, it's complicated, no question. PEG-ylated, non-PEG-ylated on top. Maybe this i.v. modified release formulations are as complicated as inhalative stuff...

But what I was asking for is the finding of the paper that depending on the T/R of the release rate the most appropriate/sensitive parameter should vary. Is that real or not? I can't make sense out of this (without reading the original paper, no 41.59 € worth for me...).

Let's say: if T releases faster than R, take AUCpart 0-24h. But if I switch T and R the same does not apply. Why that? I don't get it....

Kindest regards, nobody

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