Bioequivalence and Bioavailability Forum • What is clinically relevant?

What is clinically relevant? [Design Issues]

posted by nobody – 2018-04-05 12:04 (2541 d 05:09 ago) – Posting: # 18643
Views: 6,590

Hi Felix Austria!

Yeah, it's complicated, no question. PEG-ylated, non-PEG-ylated on top. Maybe this i.v. modified release formulations are as complicated as inhalative stuff...

But what I was asking for is the finding of the paper that depending on the T/R of the release rate the most appropriate/sensitive parameter should vary. Is that real or not? I can't make sense out of this (without reading the original paper, no 41.59 € worth for me...).

Let's say: if T releases faster than R, take AUCpart 0-24h. But if I switch T and R the same does not apply. Why that? I don't get it....

—
Kindest regards, nobody

Complete thread:

Counterintuitive? nobody 2018-04-03 11:16 [Design Issues]
- Counterintuitive? bebac_fan 2018-04-03 18:20
  - Counterintuitive? nobody 2018-04-03 23:25
    - Counterintuitive? bebac_fan 2018-04-04 00:43
      - Counterintuitive? nobody 2018-04-04 11:03
  - What is clinically relevant? Helmut 2018-04-04 16:49
    - What is clinically relevant?nobody 2018-04-05 10:04
    - What is clinically relevant? bebac_fan 2018-04-05 14:19
      - What is clinically relevant? nobody 2018-04-06 09:22
      - What is clinically relevant? Helmut 2018-04-06 16:10
        
        What is clinically relevant? bebac_fan 2018-04-06 20:53
        
        What is clinically relevant? Helmut 2018-04-06 22:05
        
        Korsmeyer–Peppas’ model mittyri 2018-04-06 23:36