What is clinically relevant? [Design Issues]

posted by nobody – 2018-04-05 10:04 (1595 d 08:56 ago) – Posting: # 18643
Views: 5,148

Hi Felix Austria!

Yeah, it's complicated, no question. PEG-ylated, non-PEG-ylated on top. Maybe this i.v. modified release formulations are as complicated as inhalative stuff...

But what I was asking for is the finding of the paper that depending on the T/R of the release rate the most appropriate/sensitive parameter should vary. Is that real or not? I can't make sense out of this (without reading the original paper, no 41.59 € worth for me...).

Let's say: if T releases faster than R, take AUCpart 0-24h. But if I switch T and R the same does not apply. Why that? I don't get it....

Kindest regards, nobody

Complete thread:

UA Flag
Activity
 Admin contact
22,305 posts in 4,668 threads, 1,587 registered users;
online 13 (1 registered, 12 guests [including 8 identified bots]).
Forum time: Wednesday 19:00 CEST (Europe/Vienna)

There is no point in being precise when you don’t know
what you’re talking about.    attributed to John Tukey

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5