Bioequivalence and Bioavailability Forum • Counterintuitive?

Counterintuitive? [Design Issues]

posted by nobody – 2018-04-03 23:25 (1388 d 23:08 ago) – Posting: # 18636
Views: 5,257

Hi BF!

» If the liposomal formulations leached more quickly (E.g. RELt > RELr), the drug would switch from flip-flop kinetics to standard kinetics.

Might be, but not necessarily. Or? ;-)

Why should the ratio of REL influence the appropriate metric for BE? Switching T and R should not influence the test in my opinion...

—
Kindest regards, nobody

Complete thread:

Counterintuitive? nobody 2018-04-03 11:16 [Design Issues]
- Counterintuitive? bebac_fan 2018-04-03 18:20
  - Counterintuitive?nobody 2018-04-03 23:25
    - Counterintuitive? bebac_fan 2018-04-04 00:43
      - Counterintuitive? nobody 2018-04-04 11:03
  - What is clinically relevant? Helmut 2018-04-04 16:49
    - What is clinically relevant? nobody 2018-04-05 10:04
    - What is clinically relevant? bebac_fan 2018-04-05 14:19
      - What is clinically relevant? nobody 2018-04-06 09:22
      - What is clinically relevant? Helmut 2018-04-06 16:10
        
        What is clinically relevant? bebac_fan 2018-04-06 20:53
        
        What is clinically relevant? Helmut 2018-04-06 22:05
        
        Korsmeyer–Peppas’ model mittyri 2018-04-06 23:36