Bioequivalence and Bioavailability Forum • Counterintuitive?

Counterintuitive? [Design Issues]

posted by nobody – 2018-04-03 13:16 (2008 d 03:50 ago) – Posting: # 18634
Views: 6,191

Hy!

Found this Easter egg:

https://link.springer.com/article/10.1007/s11095-018-2387-4?

...only read the abstract, but the findings and Conclusion are not really intuitive to me (still in mild post-prandial coma, I must admit). Why should the most appropriate AUC metric depend on the release rate of the Test product relative to reference?

Any ideas how to wrap my head around this?

—
Kindest regards, nobody

Complete thread:

Counterintuitive?nobody 2018-04-03 11:16 [Design Issues]
- Counterintuitive? bebac_fan 2018-04-03 18:20
  - Counterintuitive? nobody 2018-04-03 23:25
    - Counterintuitive? bebac_fan 2018-04-04 00:43
      - Counterintuitive? nobody 2018-04-04 11:03
  - What is clinically relevant? Helmut 2018-04-04 16:49
    - What is clinically relevant? nobody 2018-04-05 10:04
    - What is clinically relevant? bebac_fan 2018-04-05 14:19
      - What is clinically relevant? nobody 2018-04-06 09:22
      - What is clinically relevant? Helmut 2018-04-06 16:10
        
        What is clinically relevant? bebac_fan 2018-04-06 20:53
        
        What is clinically relevant? Helmut 2018-04-06 22:05
        
        Korsmeyer–Peppas’ model mittyri 2018-04-06 23:36