Bioequivalence and Bioavailability Forum • other than 90% CI in BE study?

other than 90% CI in BE study? [R for BE/BA]

posted by Helmut – Vienna, Austria, 2018-03-15 16:18 (1363 d 17:57 ago) – Posting: # 18554
Views: 8,176

Hi roro2907,

» I am just curious as I am reviewing a BE study which has used a 94.12 confidence interval. Do you have any ideas as to why this is?

As Yung-jin assumed it smells of a Two-Stage Design of the Potvin flavour. It would need a major rewrite of bear because we not only need an option to specify an adjusted α (which is always <0.05) but – if the study proceeded to the second stage – “stage” in the model. BTW, you might face different CIs in the future (see this presentation).

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Helmut Schütz

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Complete thread:

Error in Number of Subjects roro2907 2018-03-14 10:43 [R for BE/BA]
- Error in Number of Subjects yjlee168 2018-03-14 11:07
  - Error in Number of Subjects roro2907 2018-03-14 11:28
    - Error in Number of Subjects yjlee168 2018-03-14 11:54
      - Error in Number of Subjects roro2907 2018-03-14 12:54
        
        Error in Number of Subjects yjlee168 2018-03-14 13:07
        
        Error in Number of Subjects roro2907 2018-03-14 13:08
        
        Error in Number of Subjects yjlee168 2018-03-14 13:32
        
        Error in Number of Subjects roro2907 2018-03-14 13:41
        Error in Number of Subjects roro2907 2018-03-14 16:03
        
        other than 90% CI in BE study? yjlee168 2018-03-14 19:14
        
        other than 90% CI in BE study? roro2907 2018-03-15 10:19
        
        Is it a two-stage BE study? yjlee168 2018-03-15 11:48
        
        Is it a two-stage BE study? roro2907 2018-03-15 17:51
        
        other than 90% CI in BE study?Helmut 2018-03-15 16:18
        
        other than 90% CI in BE study? roro2907 2018-03-15 17:53
        
        Homework Helmut 2018-03-16 10:57