known.designs() [General Statistics]
❝ I thought about the 'paired' design as I looked into known designs(), but I was not sure.
You were guessing right.
❝ […] in several instances it happens that in period 1 a subject receives what is called the 'probe' while in period 2 it receives the "probe+investigational drug".
Designed without consulting a statistician? Lacking period effects is a strong assumption.
The only designs where a paired design is common is assessing linear PK of a new drug. Such a study starts with a single dose followed by saturation and another profile in (pseudo) steady state. Then we compare AUC0–τ (MD) with AUC0–∞ (SD). Performing such a study as a crossover would be a logistic nightmare. Never ever have seen one.
❝ I'm trying to find the CV intra associated with a particular "probe" based on DDI study in a published paper (no CV intra, just PE, CI, and N), as I need to use it in the sample size determination (precision only, no power) for a new DDI. Would 'paired' cover this situation?
Yes.
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Complete thread:
- intra-subject variability from CI verstc 2018-02-26 10:15 [General Statistics]
- intra-subject variability from CI d_labes 2018-02-26 12:26
- intra-subject variability from CI verstc 2018-02-26 13:41
- intra-subject variability from CI Helmut 2018-02-26 13:51
- intra-subject variability from CI Louis52 2018-03-09 14:27
- known.designs() Helmut 2018-03-09 14:39
- known.designs() Louis52 2018-03-09 15:13
- known.designs()Helmut 2018-03-09 15:42
- known.designs() Louis52 2018-03-09 15:13
- known.designs() Helmut 2018-03-09 14:39
- intra-subject variability from CI Louis52 2018-03-09 14:27
- intra-subject variability from CI d_labes 2018-02-26 12:26