Bioequivalence and Bioavailability Forum

known.designs() [General Statistics]

posted by Helmut – Vienna, Austria, 2018-03-09 15:39 (2511 d 06:09 ago) – Posting: # 18511
Views: 5,571

Hi Louis,

❝ […] something like CVfromCI but based on a DDI rather than BE? Let's say a DDI with one sequence for which we know the PE and CLs for the GMR (test vs. reference).

One sequence? Are you thinking about a paired design? IMHO, DDI studies should be performed as crossovers. In paired designs you have to assume (!) that there are no period effects. However, if you have data of such a study, use e.g.,

library(PowerTOST) CVfromCI(lower=0.89, upper=1.15, n=24, design="paired") # [1] 0.2634199

BTW, the function CVfromCI() (alias CI2CV()) supports all designs listed in known.designs().

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Complete thread:

intra-subject variability from CI verstc 2018-02-26 10:15 [General Statistics]
- intra-subject variability from CI d_labes 2018-02-26 12:26
  - intra-subject variability from CI verstc 2018-02-26 13:41
- intra-subject variability from CI Helmut 2018-02-26 13:51
  - intra-subject variability from CI Louis52 2018-03-09 14:27
    - known.designs()Helmut 2018-03-09 14:39
      - known.designs() Louis52 2018-03-09 15:13
        
        known.designs() Helmut 2018-03-09 15:42

known.designs() [General Sta­tis­tics]

Complete thread:

known.designs() [General Statistics]