## known.designs() [General Sta­tis­tics]

Hi Louis,

» […] something like CVfromCI but based on a DDI rather than BE? Let's say a DDI with one sequence for which we know the PE and CLs for the GMR (test vs. reference).

One sequence? Are you thinking about a paired design? IMHO, DDI studies should be performed as crossovers. In paired designs you have to assume (!) that there are no period effects. However, if you have data of such a study, use e.g.,

library(PowerTOST) CVfromCI(lower=0.89, upper=1.15, n=24, design="paired") # [1] 0.2634199

BTW, the function CVfromCI() (alias CI2CV()) supports all designs listed in known.designs().

Dif-tor heh smusma 🖖
Helmut Schütz

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