known.designs() [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2018-03-09 14:39 (1327 d 15:07 ago) – Posting: # 18511
Views: 4,269

Hi Louis,

» […] something like CVfromCI but based on a DDI rather than BE? Let's say a DDI with one sequence for which we know the PE and CLs for the GMR (test vs. reference).

One sequence? Are you thinking about a paired design? IMHO, DDI studies should be performed as crossovers. In paired designs you have to assume (!) that there are no period effects. However, if you have data of such a study, use e.g.,

CVfromCI(lower=0.89, upper=1.15, n=24, design="paired")

# [1] 0.2634199

BTW, the function CVfromCI() (alias CI2CV()) supports all designs listed in known.designs().

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

 Admin contact
21,758 posts in 4,550 threads, 1,544 registered users;
online 8 (0 registered, 8 guests [including 6 identified bots]).
Forum time: Wednesday 06:47 CEST (Europe/Vienna)

There ain’t no rules around here!
We’re trying to accomplish something!    Thomas Alva Edison

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz