Bioequivalence and Bioavailability Forum

Dear Martin,

thanks for trying to help.
I am using the lsmeans package, of course. I read the documentation.

From your post and the code in it I am unfortunately none the wiser. That is not your fault, of course, but it is regrettable at my end nonetheless.

Could you explain the relation between my questions and the example given?
It isn't so much per se how to get LSMeans that concerns me the most (use the package and get them, as simple as that, full stop).
Rather what concerns me is the idea of LSMean differences not being maximum likelihood differences, and on basis of that the rationale, if any, of using the LSMean differences in stead of maximum likelihood differences (treatment effects from the model fit).