Therapeutic Occupancy Time [Regulatives / Guidelines]
Hi Heritage,
T>MIC (actually t≥MIC) is called “Therapeutic Occupancy Time” (see this post). That’s a PK metric, not a PD endpoint. We performed such a study (antibiotic, MR vs. IR) a while ago. Be aware that
We performed a crossover in healthy subjects where we had three MICs.
❝ Thank you for valuable inputs. Do we evaluate T>MIC always in patients or it can be done in healthy vouln.?
T>MIC (actually t≥MIC) is called “Therapeutic Occupancy Time” (see this post). That’s a PK metric, not a PD endpoint. We performed such a study (antibiotic, MR vs. IR) a while ago. Be aware that
- MIC generally is an in vitro concentration. For most antibiotics in vivo MIC is based on a wacky calculation.
- For
most(all?) antibiotics there is more than one MIC (different strains of bacteria show different susceptibilities).
We performed a crossover in healthy subjects where we had three MICs.
- Confirmatory: One-sided test for the Occupancy Times (superiority).
- Exploratory: AUC (two-sided).
- Descriptive: Cmax (no CI).
—
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- T>MIC for Anti microbial is sufficient to show therapeutic efficacy heritage 2018-02-17 07:32 [Regulatives / Guidelines]
- T>MIC for Anti microbial is sufficient to show therapeutic efficacy ElMaestro 2018-02-17 12:11
- T>MIC for Anti microbial is sufficient to show therapeutic efficacy heritage 2018-02-17 14:26
- T>MIC for Anti microbial is sufficient to show therapeutic efficacy ElMaestro 2018-02-17 18:13
- Therapeutic Occupancy TimeHelmut 2018-02-17 21:27
- Therapeutic Occupancy Time heritage 2018-02-18 07:19
- T>MIC for Anti microbial is sufficient to show therapeutic efficacy heritage 2018-02-17 14:26
- T>MIC for Anti microbial is sufficient to show therapeutic efficacy ElMaestro 2018-02-17 12:11