Therapeutic Occupancy Time [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2018-02-17 22:27 (1859 d 20:56 ago) – Posting: # 18431
Views: 3,217

Hi Heritage,

❝ Thank you for valuable inputs. Do we evaluate T>MIC always in patients or it can be done in healthy vouln.?

T>MIC (actually tMIC) is called “Therapeutic Occupancy Time” (see this post). That’s a PK metric, not a PD endpoint. We performed such a study (antibiotic, MR vs. IR) a while ago. Be aware that@ElMaestro: Forget patients. You will never find ones with the same grade of infection. Parallel design difficult. Crossover impossible.

We performed a crossover in healthy subjects where we had three MICs.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
 Admin contact
22,548 posts in 4,723 threads, 1,606 registered users;
14 visitors (0 registered, 14 guests [including 11 identified bots]).
Forum time: 19:24 CET (Europe/Vienna)

You can’t really say “similar” if it’s the same again you want.
“Similar” means something different.    Anthony Burgess

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz