Therapeutic Occupancy Time [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2018-02-17 21:27 (1600 d 21:01 ago) – Posting: # 18431
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Hi Heritage,

» Thank you for valuable inputs. Do we evaluate T>MIC always in patients or it can be done in healthy vouln.?

T>MIC (actually tMIC) is called “Therapeutic Occupancy Time” (see this post). That’s a PK metric, not a PD endpoint. We performed such a study (antibiotic, MR vs. IR) a while ago. Be aware that@ElMaestro: Forget patients. You will never find ones with the same grade of infection. Parallel design difficult. Crossover impossible.

We performed a crossover in healthy subjects where we had three MICs.

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