So you made a baseline correction and now the team discusses ANCOVA [General Sta­tis­tics]

posted by martin  – Austria, 2018-02-15 18:14 (2698 d 22:55 ago) – Posting: # 18424
Views: 5,832

Dear Everbody,

Dealing with endogenous compounds is tricky and here are some more thoughts you may find helpful

This could be considered as change from baseline problem and you may have a look at Stephen Senns work on this topic relating to ANCOVA (e.g. Statist. Med. 2006; 25:4334–4344. https://doi.org/10.1002/sim.2682 )

You may find also this article of interest addressing adjustment of endogenous levels in PK modeling: Bauer, A. & Wolfsegger, M.J. Eur J Clin Pharmacol (2014) 70: 1465. https://doi.org/10.1007/s00228-014-1759-x

Best regards & hope this helps

Martin

Complete thread:

UA Flag
Activity
 Admin contact
23,428 posts in 4,929 threads, 1,681 registered users;
105 visitors (0 registered, 105 guests [including 19 identified bots]).
Forum time: 18:09 CEST (Europe/Vienna)

No matter what side of the argument you are on,
you always find people on your side
that you wish were on the other.    Thomas Berger

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5