So you made a baseline correction and now the team discusses ANCOVA [General Sta­tis­tics]

posted by martin  – Austria, 2018-02-15 18:14 (2318 d 19:24 ago) – Posting: # 18424
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Dear Everbody,

Dealing with endogenous compounds is tricky and here are some more thoughts you may find helpful

This could be considered as change from baseline problem and you may have a look at Stephen Senns work on this topic relating to ANCOVA (e.g. Statist. Med. 2006; 25:4334–4344. https://doi.org/10.1002/sim.2682 )

You may find also this article of interest addressing adjustment of endogenous levels in PK modeling: Bauer, A. & Wolfsegger, M.J. Eur J Clin Pharmacol (2014) 70: 1465. https://doi.org/10.1007/s00228-014-1759-x

Best regards & hope this helps

Martin

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