So you made a baseline correction and now the team discusses ANCOVA [General Sta­tis­tics]

posted by martin  – Austria, 2018-02-15 18:14 (1870 d 11:16 ago) – Posting: # 18424
Views: 4,072

Dear Everbody,

Dealing with endogenous compounds is tricky and here are some more thoughts you may find helpful

This could be considered as change from baseline problem and you may have a look at Stephen Senns work on this topic relating to ANCOVA (e.g. Statist. Med. 2006; 25:4334–4344. )

You may find also this article of interest addressing adjustment of endogenous levels in PK modeling: Bauer, A. & Wolfsegger, M.J. Eur J Clin Pharmacol (2014) 70: 1465.

Best regards & hope this helps


Complete thread:

UA Flag
 Admin contact
22,559 posts in 4,725 threads, 1,607 registered users;
12 visitors (0 registered, 12 guests [including 7 identified bots]).
Forum time: 06:31 CEST (Europe/Vienna)

The penalty for scientific irrelevance is, of course,
that the statistician’s work is ignored by the scientific community.    George E.P. Box

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz