Put the sickle to the corn [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2018-02-13 02:37 (2352 d 13:15 ago) – Posting: # 18409
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Dear Astea,

may I call you Nasty as well?

❝ I may suppose there were some problems in your Acetylsalicylic acid study - may be in stability…


Samples put in an ice-bath until centrifugation, plasma diluted 1:1 with 5% o-phosphoric acid for stabilization.

❝ … or inadequate sampling time,


Hhm. 00:05, 00:10, 00:15, 00:20, 00:30, 00:40, 00:50, 01:00, 01:20, 01:40, 02:00, 02:30, 03:00, 04:00, 06:00, 08:00, 10:00, 12:00 hours. No problems with "first point Cmax".


❝ … did you measure also salicylic acid?


Sure. Nice rho (see in the list above).

[image]

❝ What was the dose?


100 mg ASA (actually 5 × 20 mg tablets).

I recalculated the entire study (October 1997!) from raw-data (nasty!). Maximum residual AUC in any of the 24 subjects 7%. CVintra: ASA 18.3% (Cmax), 11.8% (AUC0–t); SA 9.58% (Cmax), 8.71% (AUC0–t). Both ASA and SA passed BE with flying colors.

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