## Put the sickle to the corn [General Sta­tis­tics]

Dear Astea,

may I call you Nasty as well?

❝ I may suppose there were some problems in your Acetylsalicylic acid study - may be in stability…

Samples put in an ice-bath until centrifugation, plasma diluted 1:1 with 5% o-phosphoric acid for stabilization.

❝ … or inadequate sampling time,

Hhm. 00:05, 00:10, 00:15, 00:20, 00:30, 00:40, 00:50, 01:00, 01:20, 01:40, 02:00, 02:30, 03:00, 04:00, 06:00, 08:00, 10:00, 12:00 hours. No problems with "first point Cmax".

❝ … did you measure also salicylic acid?

Sure. Nice rho (see in the list above).

❝ What was the dose?

100 mg ASA (actually 5 × 20 mg tablets).

I recalculated the entire study (October 1997!) from raw-data (nasty!). Maximum residual AUC in any of the 24 subjects 7%. CVintra: ASA 18.3% (Cmax), 11.8% (AUC0–t); SA 9.58% (Cmax), 8.71% (AUC0–t). Both ASA and SA passed BE with flying colors.

Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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