Bioequivalence and Bioavailability Forum

Hammer to fall [General Sta­tis­tics]

posted by Astea – Russia, 2018-02-12 19:37 (1943 d 08:47 ago) – Posting: # 18408
Views: 14,481

Dear all!

They say that upon hearing that one of his students had dropped out to study poetry David Hilbert said: "Good, he did not have enough imagination to become a mathematician".


Dear Detleww!

❝ In that light 0.050024 is of course not an alpha-inflation. As we know from theory, the IUT ❝ principle, the combination of two TOST via and assures alpha<=0.05. Thus interpret the result as 0.05. Full stop

Thank you very much for clarification! So then it's just a numeric atavism and misinterpretation.


Dear Helmut!

❝ Get a faster machine!

I've got one, but currently my car do not provide calculations in PowerTost

I may suppose there were some problems in your Acetylsalicylic acid study - may be in stability or inadequate sampling time, did you measure also salicylic acid? What was the dose? Below are my results on ASA study (data of reference drug only): rho is 0.667, 95% CI: [0.361; 0.844]. For Test+Ref data rho is about 0.755.

Complete thread:

• Power and type I adjustment for 222BE when several PK prams considered Louis52 2018-02-07 21:04 [General Sta­tis­tics] 
  • Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-07 22:37
  • Power of two combined TOST d_labes 2018-02-08 14:12
    • The mysterious ρ Helmut 2018-02-08 21:40
      • ρ ρ ρ your boat ElMaestro 2018-02-09 09:58
        • ρ ρ ρ your boat Helmut 2018-02-09 19:20
      • ...and a bonus question ElMaestro 2018-02-09 11:32
        • ...and a bonus question Helmut 2018-02-09 19:43
          • If u see a BEar don't forget to R oaρ Astea 2018-02-09 20:47
            • package install failed d_labes 2018-02-11 13:23
      • The mysterious ρ -between or within studies d_labes 2018-02-11 15:57
        • The mysterious ρ -between or within studies Helmut 2018-02-11 17:31
          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:21
            • The mysterious ρ within studies Helmut 2018-02-11 22:44
              • The mysterious ρ within studies nobody 2018-02-12 09:08
        • The mysterious ρ -between or within studies Astea 2018-02-11 17:34
          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:36
          • The mysterious ρ within studies Helmut 2018-02-11 22:48
  • Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-11 18:43
    • Power and type I adjustment for 222BE when several PK prams considered nobody 2018-02-12 09:10
      • reminds me of something ElMaestro 2018-02-12 09:18
        • reminds me of something nobody 2018-02-12 09:38
          • Hammer to fallAstea 2018-02-12 18:37
            • Put the sickle to the corn Helmut 2018-02-13 01:37
              • Put the sickle to the corn Astea 2018-02-13 08:27
                • Put the sickle to the corn Helmut 2018-02-13 12:45
              • Put the sickle to the corn Relaxation 2018-02-13 10:37
                • multiple units, lag-times Helmut 2018-02-13 13:31